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A white laboratory rodent perched on the edge of a blue-toned glass container, possibly a test tube or a beaker

We are the leading Preclinical Neuroscience CRO specializing in rodent models of CNS diseases

We focus on providing services leveraging the best available models of ALS, Alzheimer’s Disease, Multiple Sclerosis, and Parkinson's Disease

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Rodent Models

Learn more about our thoroughly characterized and validated models of CNS diseases

We have a range of transgenic and inducible models readily available for your studies. Our team of animal model scientists will work with you to find the right model.

Amyotrophic Lateral Sclerosis (ALS)

TDP-43 mouse models with cytoplasmic aggregates, motor dysfunction, neurodegeneration, neuroinflammation, and neuromuscular changes.

Amyotrophic Lateral Sclerosis (ALS)

TDP-43 mouse models with cytoplasmic aggregates, motor dysfunction, neurodegeneration, neuroinflammation, and neuromuscular changes.

Alzheimer's Disease

β-amyloid and tau models with progressive pathologic changes in a well-defined spatiotemporal pattern.

Multiple Sclerosis (MS)

EAE, cuprizone, and other models that recapitulate the autoimmune inflammation, demyelination & remyelination, and neurodegeneration aspects of human disease.

Parkinson's Disease

α-synuclein preformed fibril (PFF) seeding & spreading models recapitulating different aspects of Parkinson's disease.

Our Services

We provide a range of specialized research services tailored to models of CNS diseases

End-to-end services from model generation to in-life testing to quantitative tissue & fluid biomarkers.

A close-up of a medical syringe with a needle inserted into a small vial, likely a therapeutic agent

Animal Services

Our animal services team are experts in dosing via multiple routes of administration, stereotaxic surgical procedures, and fluid & tissue collection.

Behavioral Testing - a three-dimensional maze with high walls, and within this maze, there's a white laboratory mouse looking out from one of the corridors.

Behavioral Testing

We use specific, validated tests that are sensitive to response to therapy in our CNS rodent models.

A digital rendering of a neuron, which is a cell that transmits nerve impulses.

Electrophysiology

We use well-established, in vivo electrophysiological measures to evaluate motor and sensory function.

A close-up of test tubes in a laboratory setting with a pipette dispensing a liquid into one of them

Fluid & Cellular Biomarkers

We can measure clinically translational biomarkers, such as neurofilament light, in blood and cerebrospinal fluid (CSF). We can also perform cellular immunophenotyping on a range of tissues, including brain, spinal cord, lymph nodes, and spleen.

A series of MRI (Magnetic Resonance Imaging) brain scans displayed on a light box or a digital screen

Histology & Tissue Analysis

We have a state-of-the-art histopathology facility specializing in tissues collected from rodent models of neurological diseases.

In Vivo Imaging of mouse brain

In Vivo Imaging

We use preclinical MRI, PET, and CT scanners, coupled with our advanced image processing & analysis techniques, to non-invasively measure changes in brain & muscle structure (e.g. atrophy) and function (e.g. metabolism, blood flow).

Our Latest Innovations

Narrated presentations of our scientific advancements

Resources

Up-to-date information on topics and best practices related to the evaluation of therapeutic agents in animal models of neurological diseases

Low magnification view of human pan-TDP-43 pathology in the spinal cord
ALS Mouse Models for Drug Development
A guide to the most effective use of research animal models of Amyotrophic Lateral Sclerosis (ALS) for preclinical testing of therapeutics.
Illustration showing NfL levels in CSF of the mouse brain
Neurofilament Light Chain in Parkinson's Disease Models
How neurofilament light chain (NfL; NF-L) levels can be used as a blood & CSF biomarker in Parkinson's disease mouse and rat models.
Demyelination & Remyelination in the Cuprizone Model
An overview of the methods available to measure myelin and oligodendrocytes in the cuprizone demyelination mouse model of multiple sclerosis (MS).
EAE in the mouse spinal cord
Axonal Injury in Experimental Autoimmune Encephalomyelitis (EAE)
This resource describes the methods available for measuring axonal damage & axon degeneration, including tissue markers and plasma & CSF neurofilament light chain (NfL; NF-L) levels, in the EAE model of multiple sclerosis (MS).
TDP-43 ΔNLS (rNLS8) Mice for ALS Drug Development
This resource provides information about the use of the ΔNLS (deltaNLS, hTDP-43ΔNLS, hTDP-43DeltaNLS, dNLS, TDP43 NLS, rNLS8) TDP-43 transgenic mouse model of ALS for preclinical therapeutic studies.
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Contact Us

Let us know what you’re interested in. Our team will be happy to discuss with you!

Email us at i[email protected] or simply complete & submit the form below. 

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