Rodent Models
Learn more about our thoroughly characterized and validated animal models of neurological diseases
We have a range of transgenic and inducible mouse & rat models readily available for your studies. Our team of animal model scientists will work with you to find the right model.
CRO Services
We provide a range of specialized research services tailored to models of CNS diseases
End-to-end contract research services from model generation to in-life testing to quantitative tissue & fluid biomarkers.
- Animal Services
- Behavioral Testing
- Electrophysiology
- Fluid & Cellular Biomarkers
- Histology & Tissue Analysis
- In Vivo Imaging
Animal Services
Our animal services team are experts in dosing via multiple routes of administration, stereotaxic surgical procedures, and fluid & tissue collection.
Behavioral Testing
We use specific, validated tests that are sensitive to response to therapy in our CNS rodent models.
Electrophysiology
We use well-established, in vivo electrophysiological measures to evaluate motor and sensory function.
Fluid & Cellular Biomarkers
We can measure clinically translational biomarkers, such as neurofilament light, in blood and cerebrospinal fluid (CSF). We can also perform cellular immunophenotyping on a range of tissues, including brain, spinal cord, lymph nodes, and spleen.
Histology & Tissue Analysis
We have a state-of-the-art histopathology facility specializing in tissues collected from rodent models of neurological diseases.
In Vivo Imaging
We use preclinical MRI, PET, and CT scanners, coupled with our advanced image processing & analysis techniques, to non-invasively measure changes in brain & muscle structure (e.g. atrophy) and function (e.g. metabolism, blood flow).
Our Latest Innovations
Narrated presentations of our scientific advancements
Microglial Activation in an α-Synuclein PFF Mouse Model
We have quantified microglial activation, based on morphology, in an α-synuclein preformed fibril (PFF) seeding & spreading mouse model of Parkinson’s disease.
Amyloid-β & Inflammatory Microenvironment in Alzheimer's Mice
We have analyzed the complex spatial relationships between β-amyloid plaques, activated & resting microglia, and astrocytes in an APP/PS1 transgenic model.
Brain Atrophy Analysis in Mouse Models of Neurodegeneration
Automated in vivo MRI-based quantitative brain atrophy measures (regional brain volumes and cortical thickness) from mouse models of ALS & Parkinson's disease.