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A white laboratory rodent perched on the edge of a blue-toned glass container, possibly a test tube or a beaker

We are the leading Preclinical Neuroscience CRO specializing in animal models of CNS diseases

We focus on providing research services leveraging the best available models of ALS, Alzheimer’s Disease, Multiple Sclerosis, and Parkinson's Disease

Our Neuroscience Animal ModelsOur Preclinical CRO Services
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Visit our Clinical Imaging CRO Website

We provide Imaging Core Lab services for clinical trials of neurological diseases.

Imaging CRO Services

Rodent Models

Learn more about our thoroughly characterized and validated animal models of neurological diseases

We have a range of transgenic and inducible mouse & rat models readily available for your studies. Our team of animal model scientists will work with you to find the right model.

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Staining used to highlight areas of neuronal degeneration or the presence of inclusions characteristic of the disease within the nervous system tissue
Amyotrophic Lateral Sclerosis (ALS)

TDP-43 mouse models with cytoplasmic aggregates, motor dysfunction, neurodegeneration, neuroinflammation, and neuromuscular changes.

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Staining used to highlight areas of neuronal degeneration or the presence of inclusions characteristic of the disease within the nervous system tissue
Amyotrophic Lateral Sclerosis (ALS)

TDP-43 mouse models with cytoplasmic aggregates, motor dysfunction, neurodegeneration, neuroinflammation, and neuromuscular changes.

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Alzheimer’s Disease - IHC staining
Alzheimer's Disease

Amyloid-β and tau models with progressive pathologic changes in a well-defined spatiotemporal pattern.

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Multiple Sclerosis - a histological section of neural tissue stained to show cellular and structural details
Multiple Sclerosis (MS)

EAE, cuprizone, and other models that recapitulate the autoimmune inflammation, demyelination & remyelination, and neurodegeneration aspects of human disease.

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Parkinson's Disease - IHC staining
Parkinson's Disease

α-Synuclein preformed fibril (PFF) seeding & spreading models and AAV-induced α-synuclein mouse models recapitulating different aspects of Parkinson's disease.

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CRO Services

We provide a range of specialized research services tailored to models of CNS diseases

End-to-end contract research services from model generation to in-life testing to quantitative tissue & fluid biomarkers.

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A close-up of a medical syringe with a needle inserted into a small vial, likely a therapeutic agent

Animal Services

Our animal services team are experts in dosing via multiple routes of administration, stereotaxic surgical procedures, and fluid & tissue collection.

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Behavioral Testing - a three-dimensional maze with high walls, and within this maze, there's a white laboratory mouse looking out from one of the corridors.

Behavioral Testing

We use specific, validated tests that are sensitive to response to therapy in our CNS rodent models.

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A digital rendering of a neuron, which is a cell that transmits nerve impulses.

Electrophysiology

We use well-established, in vivo electrophysiological measures to evaluate motor and sensory function.

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A close-up of test tubes in a laboratory setting with a pipette dispensing a liquid into one of them

Fluid & Cellular Biomarkers

We can measure clinically translational biomarkers, such as neurofilament light, in blood and cerebrospinal fluid (CSF). We can also perform cellular immunophenotyping on a range of tissues, including brain, spinal cord, lymph nodes, and spleen.

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A series of MRI (Magnetic Resonance Imaging) brain scans displayed on a light box or a digital screen

Histology & Tissue Analysis

We have a state-of-the-art histopathology facility specializing in tissues collected from rodent models of neurological diseases.

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In Vivo Imaging of mouse brain

In Vivo Imaging

We use preclinical MRI, PET, and CT scanners, coupled with our advanced image processing & analysis techniques, to non-invasively measure changes in brain & muscle structure (e.g. atrophy) and function (e.g. metabolism, blood flow).

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Our Latest Innovations

Narrated presentations of our scientific advancements

Scientific Resources

Up-to-date information on topics and best practices related to the evaluation of therapeutic agents in animal models of neurological diseases

Illustration of motor neuron synapsing with a skeletal muscle fiber
Neuromuscular Junction (NMJ) Morphology & ALS Models
Insights into neuromuscular junction (NMJ), its role in amyotrophic lateral sclerosis (ALS), and tools & methods used to study morphological changes in NMJs.
Illustration of astrocytes tiling the CNS
Astrocyte Morphology in Alzheimer’s Disease
An overview of astrocyte morphological analysis and the applications to neurodegenerative disease research and drug discovery & development.
ALS Mouse Models & Spinal Motor Neurons
An overview of the involvement of spinal motor neurons in disease progression in mouse models of Amyotrophic Lateral Sclerosis (ALS).
AAV α-Synuclein Models for Parkinson’s Disease Drug Development
Overview of adeno-associated virus (AAV) induced α-synuclein expression in mouse & rat models for use in preclinical studies of disease-modifying therapeutics.
Demyelination & Remyelination in the Cuprizone Model
An overview of the methods available to measure myelin and oligodendrocytes in the cuprizone demyelination mouse model of multiple sclerosis (MS).
Illustration showing NfL levels in CSF of the mouse brain
Neurofilament Light Chain in Parkinson's Disease Models
How neurofilament light chain (NfL; NF-L) levels can be used as blood (plasma; serum) & CSF biomarkers in Parkinson's disease mouse and rat models.
EAE in the mouse spinal cord
Experimental Autoimmune Encephalomyelitis (EAE) & Axonal Injury
This resource describes the methods available for measuring axonal damage & axon degeneration, including tissue markers and plasma & CSF neurofilament light chain (NfL; NF-L) levels, in the EAE model of multiple sclerosis (MS).
TDP-43 ΔNLS (rNLS8) Mice for ALS Drug Development
This resource provides information about the use of the ΔNLS (deltaNLS, hTDP-43ΔNLS, hTDP-43DeltaNLS, dNLS, TDP43 NLS, rNLS8) TDP-43 transgenic mouse model of ALS for preclinical therapeutic studies.
Microglia Morphology in ALS, Alzheimer’s Disease & Parkinson’s Disease
An overview of microglial morphological analysis and the applications to neurodegenerative disease research and drug discovery & development.
Various types of amyloid-β plaques
Amyloid-β Plaque Analysis in Alzheimer’s Disease
Overview of methods to classify & quantify Aβ plaques in brain tissue sections from humans & Alzheimer’s disease animal models (transgenic mice & rats).
Low magnification view of human pan-TDP-43 pathology in the spinal cord
ALS Mouse Models for Drug Development
A guide to the most effective use of research animal models (mouse & rat models) of Amyotrophic Lateral Sclerosis (ALS) for preclinical testing of therapeutics.
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