Initiative Overview
Microglia and astrocytes play a central role in neurodegenerative diseases, such as ALS, Alzheimer's Disease & Tauopathies, and Parkinson's Disease. Through a combination of reviews of the latest scientific advances, as well as Biospective's original research studies, we seek to explore the current understanding of the associations between neuroinflammatory cells and neurodegeneration, as well as approaches for disease modification through therapeutic intervention.
TNF-α & Microglia in Neurodegenerative Diseases
An overview of the function of tumor necrosis factor-alpha (TNF-α) in microglia and its contribution to the progression of neurodegeneration.
Astrocyte Morphology in Alzheimer’s Disease
An overview of astrocyte morphological analysis and the applications to neurodegenerative disease research and drug discovery & development.
NLRP3 Inflammasome and Neurodegenerative Diseases
An overview of the NLRP3 inflammasome and its role in neurodegenerative diseases, including Alzheimer's disease, Parkinson’s disease, and ALS.
Microglial Senescence and Neurodegenerative Diseases
An overview of microglial senescence and its role in neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD).
Astrocytes & Amyloid-β Mouse Models of Alzheimer's Disease
Analysis of astrocyte morphology in the amyloid-β plaque microenvironment provides a sensitive measure of disease progression in transgenic mice.
Lysosome Dysfunction in Microglia & Astrocytes
An overview of lysosomal dysfunction in microglia & astrocytes, and its role in neurodegenerative diseases.
Microglia Morphology in ALS, Alzheimer's Disease & Parkinson's Disease
An overview of microglial morphological analysis and the applications to neurodegenerative disease research and drug discovery & development.
