Initiative Overview
Microglia and astrocytes play a central role in neurodegenerative diseases, such as ALS, Alzheimer's Disease & Tauopathies, and Parkinson's Disease. Through a combination of reviews of the latest scientific advances, as well as Biospective's original research studies, we seek to explore the current understanding of the associations between neuroinflammatory cells and neurodegeneration, as well as approaches for disease modification through therapeutic intervention.
What is NF-κB (Nuclear Factor Kappa B)?
An overview of NF-κB, highlighting its role in inflammation and diseases (including neurological disorders), and therapeutic strategies targeting NF-κB.
TMEM119 (transmembrane protein 119) and Microglia
An overview of the significance of TMEM119 in labeling microglia and its role in various diseases, including Alzheimer’s disease.
Pyroptosis - A Target for Drug Development
An overview of pyroptosis, its role in various diseases, and therapeutic strategies related to pyroptosis pathways.
TREM2, Microglia and Neuroinflammation
An overview of TREM2, its role in microglia, links to neurodegenerative diseases, and potential treatment implications.
APOE4, Microglia & Alzheimer’s Disease
An overview of how ApoE4 influences microglial activity in Alzheimer's disease and the development of targeted therapeutics.
Interleukin-1 Beta (IL-1β) and Neurodegenerative Diseases
The role of IL-1beta in neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS).
The Inflammasome – A Target for Therapeutic Development for Multiple Diseases
An overview of inflammasomes, including their mechanisms of action, roles in diseases, and targeting for drug development.
What is IL-1β (Interleukin-1 Beta)?
An overview of IL-1β, its proinflammatory role in systemic and neurological diseases, and therapeutic strategies involving IL-1β antagonism.
NLRP3 – A Target for Neuroscience Drug Development
An overview of NLRP3 inflammasome activation triggers, disease associations, and therapeutic targeting strategies.
Impaired Microglia Autophagy in Neurodegenerative Diseases
How impaired microglial autophagy contributes to the progression of neurodegenerative diseases.
Microglia-Neuron Interactions & Neurodegenerative Diseases
A concise review of the direct interactions between microglia & neurons, and how these cell-to-cell interactions may be affected in neurodegenerative diseases.
Microglia, Astrocytes & Tau in Neurodegenerative Diseases
How glial-driven neuroinflammation fuels tau aggregation, propagation, and neuronal loss in Alzheimer’s disease and other tauopathies.
