Initiative Overview
Microglia and astrocytes play a central role in neurodegenerative diseases, such as ALS, Alzheimer's Disease & Tauopathies, and Parkinson's Disease. Through a combination of reviews of the latest scientific advances, as well as Biospective's original research studies, we seek to explore the current understanding of the associations between neuroinflammatory cells and neurodegeneration, as well as approaches for disease modification through therapeutic intervention.
What is NLRP3?
An overview of NLRP3 and NLRP3 inflammasome activation triggers, disease associations, and therapeutic targeting strategies.
Impaired Microglia Autophagy in Neurodegenerative Diseases
How impaired microglial autophagy contributes to the progression of neurodegenerative diseases.
Microglia-Neuron Interactions & Neurodegenerative Diseases
A concise review of the direct interactions between microglia & neurons, and how these cell-to-cell interactions may be affected in neurodegenerative diseases.
Microglia, Astrocytes & Tau in Neurodegenerative Diseases
How glial-driven neuroinflammation fuels tau aggregation, propagation, and neuronal loss in Alzheimer’s disease and other tauopathies.
Microglia, Astrocytes & α-Synuclein in Parkinson’s Disease
How α-synuclein influences microglia and astrocytes in Parkinson’s disease and other synucleinopathies.
Mitochondrial Dysfunction in Microglia & Astrocytes
The role of mitochondrial dysfunction in microglia and astrocytes in neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and ALS.
TNF-α & Microglia in Neurodegenerative Diseases
An overview of the function of tumor necrosis factor-alpha (TNF-α) in microglia and its contribution to the progression of neurodegeneration.
Astrocyte Morphology in Alzheimer’s Disease
An overview of astrocyte morphological analysis and the applications to neurodegenerative disease research and drug discovery & development.
NLRP3 Inflammasome and Neurodegenerative Diseases
An overview of the NLRP3 inflammasome and its role in neurodegenerative diseases, including Alzheimer's disease, Parkinson’s disease, and ALS.
Microglial Senescence and Neurodegenerative Diseases
An overview of microglial senescence and its role in neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD).
Astrocytes & Amyloid-β Mouse Models of Alzheimer's Disease
Analysis of astrocyte morphology in the amyloid-β plaque microenvironment provides a sensitive measure of disease progression in transgenic mice.
Lysosome Dysfunction in Microglia & Astrocytes
An overview of lysosomal dysfunction in microglia & astrocytes, and its role in neurodegenerative diseases.
