Preclinical CRO Services

Our animal services team are experts in dosing via multiple routes of administration, stereotaxic surgical procedures, and fluid & tissue collection.

We use specific, validated tests that are sensitive to response to therapy in our CNS rodent models.

We use well-established, in vivo electrophysiological measures to evaluate motor and sensory function.

We can measure clinically translational biomarkers, such as neurofilament light, in blood and cerebrospinal fluid (CSF). We can also perform cellular immunophenotyping on a range of tissues, including brain, spinal cord, lymph nodes, and spleen.

We have a state-of-the-art histopathology facility specializing in tissues collected from rodent models of neurological diseases.

We perform high-quality IHC studies using a range of markers tailored to our CNS disease models.

We combine multiple immunofluorescence markers on a single tissue section.

We use preclinical MRI, PET, and CT scanners, coupled with our advanced image processing & analysis techniques, to non-invasively measure changes in brain & muscle structure (e.g. atrophy) and function (e.g. metabolism, blood flow).