Preclinical WebsiteClinical Website


Biospective performs dosing of therapeutics agents via peripheral routes or directly into the CNS.

Rodent Model used for Dosing - Peripheral Administration

Peripheral Administration

We can deliver therapeutic agents via several peripheral routes of administration, including intravenous (i.v.), intraperitoneal (i.p.,), subcutaneous (s.c.), intramuscular (i.m.), and intranasal (i.n.). We work closely with our Sponsors to determiner the best method of delivery.

Rodent Model used for Dosing - Oral Administration

Oral Administration

For therapeutics that can be delivered orally (p.o.), there are several options. Our team is thoroughly experienced in delivery via oral gavage. Compounds can also be delivered in the chow or drinking water. In this case, we closely monitor the animal's intake.

Rodent Model used for Dosing - Direct CNS Administration

Direct CNS Administration

For therapeutic agents that do not readily cross an intact blood-brain barrier (BBB), we can administer them directly into the CNS (brain, spinal cord, or CSF). Several routes are available, including intracerebral (i.c.), intracerebroventricular (i.c.v.), intra-cisterna magna (i.c.m), lumbar puncture (l.p.), or intraspinal (i.s.). If repeated or chronic administration is required, a catheter can be inserted.

Rodent Model used for Dosing - Osmotic Pump Administration

Osmotic Pump Administration

For long-term delivery of therapeutic agents, we can use an osmotic pump. Pumps are available in various sizes with different flow rates. They are typically implanted subcutaneously and can be coupled with a catheter (e.g. for continuous i.c.v. administration).

Learn more about our Dosing Services.

Discover more of our Animal Services


How does Biospective deliver gene therapy vectors?

We have extensive experience working with gene therapy vectors, such as AAVs. These vectors can be delivered via a number of routes, including systemic administration (e.g. intravenous), intracerebral (directly injection into a specific brain region), intracerebroventricular (injection into the CSF), or intra-cisterna magna (injection into the CSF).

Can Biospective perform administration to newborn and neonatal animals?

Yes. Our team has experience with injections in pups (e.g. P0, P1) via several different routes, including intravenous (e.g. facial vein) and intracerebroventricular.

Can Biospective perform repeated i.c.m. injections?

Yes. Our team has developed substantial expertise in delivery into the cisterna magna (including mice) and we can perform repeated administrations.

More Information

Let us know what you’re interested in. Our team will be happy to discuss with you!

Email us at i[email protected] or simply complete & submit the form below. 

Phone Number*
Affiliation (Company/University)*

Your privacy is important to us. We will protect your data as outlined in our Privacy Notice.

I agree to the terms in the Privacy Notice*

We use necessary cookies to make our site work. We also use other cookies to help us make improvements by measuring how you use the site or for marketing purposes. You have the choice to accept or reject them all. For more detailed information about the cookies we use, see our Privacy Notice.