Biospective provides validated moue & rat models of neurological diseases, with particular expertise in ALS, Alzheimer's Disease, Parkinson's Disease, Tauopathies, and Multiple Sclerosis, to support preclinical drug development programs.
Our expert team is trusted by biotech and pharmaceutical companies around the world for outsourcing of their biodistribution, target engagement, mechanism-of-action, and efficacy studies across a range of therapeutic modalities (e.g. small molecules, ASOs, gene therapies, antibodies, peptides, and other biologics).
Amyotrophic Lateral Sclerosis (ALS)
TDP-43 mouse models with cytoplasmic aggregates, motor dysfunction, neurodegeneration, neuroinflammation, and neuromuscular changes.
Alzheimer's Disease & Tauopathies
Amyloid-β and tau models with progressive pathologic changes in a well-defined spatiotemporal pattern.
Multiple Sclerosis (MS)
EAE, cuprizone, and other models that recapitulate the autoimmune inflammation, demyelination & remyelination, and neurodegeneration aspects of human disease.
Parkinson's Disease
α-Synuclein preformed fibril (PFF) seeding & spreading models and AAV-induced α-synuclein mouse models recapitulating different aspects of Parkinson's disease.
