Neuroscience Animal Models

Research animal models of neurological diseases, including transgenic mice and inducible mouse & rat models, for preclinical therapeutic efficacy studies.

Two laboratory mice, which are commonly used as rodent models in biomedical research

Amyotrophic Lateral Sclerosis (ALS)

TDP-43 mouse models with cytoplasmic aggregates, motor dysfunction, neurodegeneration, neuroinflammation, and neuromuscular changes.

TDP-43 Transgenic Models

Staining used to highlight areas of neuronal degeneration or the presence of inclusions characteristic of the disease within the nervous system tissue

Alzheimer's Disease

Amyloid-β and tau models with progressive pathologic changes in a well-defined spatiotemporal pattern.

AMYLOID-β TRANSGENIC MODELS

Tau Fibril Spreading Models

Multiple Sclerosis (MS)

EAE, cuprizone, and other models that recapitulate the autoimmune inflammation, demyelination & remyelination, and neurodegeneration aspects of human disease.

Cuprizone Models

EAE Models

Multiple Sclerosis - a histological section of neural tissue stained to show cellular and structural details

Parkinson's Disease

α-Synuclein preformed fibril (PFF) seeding & spreading models and AAV-induced α-synuclein mouse models recapitulating different aspects of Parkinson's disease.

α-SYNUCLEIN PREFORMED FIBRIL (PFF) MODELS

AAV A53T α-SYNUCLEIN MOUSE MODELS