The Compound Nerve Action Potential (CNAP) measures the activity of all fibers comprising a stimulated peripheral nerve. The principle is to electrically stimulate a nerve trunk and to record, in return, the compound action potential resulting from the activity of all fibers. It serves as an excellent measure to assess the integrity and functionality of nerves in animal models.
Changes in CNAP parameters, such as reduced amplitude or altered conduction velocities, may indicate nerve damage, demyelination, or dysfunction. As such, CNAP is a valuable tool for evaluation of the effects of experimental treatments.
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What is the difference between CMAP and CNAP?
CMAP (or Compound Muscle Action Potential) measures the activity of all fibers composing the stimulated muscle ("motor nerve recording"), while CNAP (or Compound Nerve Action Potential) measures the activity of all fibers composing the stimulated nerve ("sensory nerve recording").
Can CMAP, MUNE, and CNAP be performed on the same animal?
Yes, all three measures can be obtained in a single session for each animal.
Which peripheral nerves are typically stimulated for CNAP?
We typically stimulate the caudal tail nerve for CNAP.