Can you perform CMAP, MUNE, and CNAP on the same animal?

Yes, all three measures can be obtained in a single session for each animal.

CNAP (Sensory) - Electrophysiology

Q: What is the difference between CMAP and CNAP?

CMAP (or Compound Muscle Action Potential) measures the activity of all fibers composing the stimulated muscle ("motor nerve recording"), while CNAP (or Compound Nerve Action Potential) measures the activity of all fibers composing the stimulated nerve ("sensory nerve recording").

Q: Which peripheral nerves are typically stimulated for CNAP?

We typically stimulate the caudal tail nerve for CNAP.

CNAP (Sensory)

The Compound Nerve Action Potential (CNAP) measures the activity of all fibers comprising a stimulated peripheral nerve. The principle is to electrically stimulate a nerve trunk and to record, in return, the compound action potential resulting from the activity of all fibers. It serves as an excellent measure to assess the integrity and functionality of nerves in animal models.

Changes in CNAP parameters, such as reduced amplitude or altered conduction velocities, may indicate nerve damage, demyelination, or dysfunction. As such, CNAP is a valuable tool for evaluation of the effects of experimental treatments.

Learn more about our CNAP Services.

Discover more of our Electrophysiology Services

CMAP & MUNE (Motor)

FAQs

What is the difference between CMAP and CNAP?

Can CMAP, MUNE, and CNAP be performed on the same animal?

Which peripheral nerves are typically stimulated for CNAP?

CNAP (Sensory)

We perform Compound Nerve Action Potential (CNAP) recordings to analyze sensory nerve function.

CNAP (Sensory)

Discover more of our Electrophysiology Services

CMAP & MUNE (Motor)

More Information

Let us know what you’re interested in. Our team will be happy to discuss with you!