ALS Mouse Models for Drug Development
A guide to the most effective use of research animal models (mouse & rat models) of Amyotrophic Lateral Sclerosis (ALS) for preclinical testing of therapeutics.
Neurofilament Light Chain in Parkinson's Disease Models
How neurofilament light chain (NfL; NF-L) levels can be used as blood (plasma; serum) & CSF biomarkers in Parkinson's disease mouse and rat models.
Demyelination & Remyelination in the Cuprizone Model
An overview of the methods available to measure myelin and oligodendrocytes in the cuprizone demyelination mouse model of multiple sclerosis (MS).
Experimental Autoimmune Encephalomyelitis (EAE) & Axonal Injury
This resource describes the methods available for measuring axonal damage & axon degeneration, including tissue markers and plasma & CSF neurofilament light chain (NfL; NF-L) levels, in the EAE model of multiple sclerosis (MS).
TDP-43 ΔNLS (rNLS8) Mice for ALS Drug Development
This resource provides information about the use of the ΔNLS (deltaNLS, hTDP-43ΔNLS, hTDP-43DeltaNLS, dNLS, TDP43 NLS, rNLS8) TDP-43 transgenic mouse model of ALS for preclinical therapeutic studies.
AAV α-Synuclein Models for Parkinson’s Disease Drug Development
Overview of adeno-associated virus (AAV) induced α-synuclein expression in mouse & rat models for use in preclinical studies of disease-modifying therapeutics.
Microglia Morphology in ALS, Alzheimer’s Disease & Parkinson’s Disease
An overview of microglial morphological analysis and the applications to neurodegenerative disease research and drug discovery & development.
Amyloid-β Plaque Analysis in Alzheimer’s Disease
Overview of methods to classify & quantify Aβ plaques in brain tissue sections from humans & Alzheimer’s disease animal models (transgenic mice & rats).
