ALS Mouse Models for Drug Development
A guide to the most effective use of research animal models of Amyotrophic Lateral Sclerosis (ALS) for preclinical testing of therapeutics.
Neurofilament Light Chain in Parkinson's Disease Models
How neurofilament light chain (NfL; NF-L) levels can be used as a blood & CSF biomarker in Parkinson's disease mouse and rat models.
Demyelination & Remyelination in the Cuprizone Model
An overview of the methods available to measure myelin and oligodendrocytes in the cuprizone demyelination mouse model of multiple sclerosis (MS).
Axonal Injury in Experimental Autoimmune Encephalomyelitis (EAE)
This resource describes the methods available for measuring axonal damage & axon degeneration, including tissue markers and plasma & CSF neurofilament light chain (NfL; NF-L) levels, in the EAE model of multiple sclerosis (MS).
TDP-43 ΔNLS (rNLS8) Mice for ALS Drug Development
This resource provides information about the use of the ΔNLS (deltaNLS, hTDP-43ΔNLS, hTDP-43DeltaNLS, dNLS, TDP43 NLS, rNLS8) TDP-43 transgenic mouse model of ALS for preclinical therapeutic studies.