Hypothalamic Atrophy in an AAV-Tau Mouse Model of PSP: Translational Relevance to Human Disease
Hypothalamic atrophy in PSP patients is mirrored in Biospective’s AAV-Tau mouse model, where MRI shows hypothalamic volume loss far from the nigral injection site.
Tg2576 Mice vs. APP/PS1 (ARTE10) Mice – Choosing an Amyloid-β Model for Alzheimer's Drug Development
Tg2576 vs. APP/PS1 (ARTE10) mice: amyloid onset, penetrance, variability, CAA, and how model choice changes cohort size and study timeline.
A Guide to Mouse Models of Frontotemporal Dementia (FTD)
A Resource providing a comprehensive overview of animal models used in frontotemporal dementia research, including genetic and pathological disease mechanisms.
What is the EAE (Experimental Autoimmune Encephalomyelitis) Model of Multiple Sclerosis (MS)?
An overview of EAE animal models of multiple sclerosis (MS), including pathophysiology and utilization of positive controls for preclinical therapeutic studies.
PS19 Mouse Model for Tau Targeted Drug Development
An overview of PS19 (P301S) mice as a transgenic model for preclinical evaluation of disease-modifying therapies targeting tau seeding & spreading.
Preformed Fibrils – A Guide to Cell and Animal Models
An overview of preformed fibril-induced cell & animal models for preclinical testing of disease-modifying therapies across multiple neurodegenerative diseases.
TDP-43: Role in ALS and Frontotemporal Dementia (FTD)
An overview of TDP-43, its physiological role, significance in ALS and FTD pathology, and therapeutic strategies involving TDP-43.
5xFAD Mice & APP/PS1 Mice – A Comparison of Amyloid-β Mice for Alzheimer's Drug Development
A comparison of 5xFAD and APP/PS1 mouse models of Alzheimer’s disease, including amyloid-beta pathology, neuroinflammation, and cerebrovascular disease.
Mitochondrial Dysfunction & Parkinson's Disease
An overview of how mitochondrial dysfunction is associated with neurodegeneration in Parkinson’s disease.
Mitophagy and Parkinson’s Disease
An overview of how impaired mitophagy can lead to neurodegeneration in Parkinson’s disease.
Autophagy and Transcription Factor EB (TFEB)
An overview of Transcription Factor EB (TFEB) and its role in autophagy and neurodegenerative diseases.
Autophagy & Neurodegenerative Diseases
An overview of how cellular autophagy plays a role in brain health and neurodegeneration.
