Preformed Fibrils – A Guide to Cell and Animal Models
An overview of preformed fibril-induced cell & animal models for preclinical testing of disease-modifying therapies across multiple neurodegenerative diseases.
5xFAD Mice & APP/PS1 Mice – A Comparison of Amyloid-β Mouse Models for Alzheimer's Disease Research
This Resource compares APP/PS1 & 5xFAD mouse models of Alzheimer’s disease, including amyloid-beta pathology, neuroinflammation, and cerebrovascular disease.
PS19 Mouse Model for Tau Targeted Drug Development
An overview of PS19 (P301S) mice as a transgenic model for preclinical evaluation of disease-modifying therapies targeting tau seeding & spreading.
TDP-43: Role in ALS and Frontotemporal Dementia (FTD)
TDP-43 (TAR DNA-binding protein 43) is a DNA- and RNA-binding protein that plays a central role in the pathology of amyotrophic lateral sclerosis (ALS) & frontotemporal dementia (FTD). In these neurodegenerative diseases, TDP-43 abnormally mislocalizes and aggregates in neurons and glial cells, disrupting RNA processing and contributing to progressive neuronal dysfunction. Understanding TDP-43 pathology is critical for advancing disease models, biomarkers, and therapeutic development in ALS and FTD.
What is the EAE (Experimental Autoimmune Encephalomyelitis) Model of Multiple Sclerosis (MS)?
An overview of EAE animal models of multiple sclerosis (MS), including pathophysiology and utilization of positive controls for preclinical therapeutic studies.
Mitochondrial Dysfunction & Parkinson's Disease
An overview of how mitochondrial dysfunction is associated with neurodegeneration in Parkinson’s disease.
Mitophagy and Parkinson’s Disease
An overview of how impaired mitophagy can lead to neurodegeneration in Parkinson’s disease.
Autophagy and Transcription Factor EB (TFEB)
An overview of Transcription Factor EB (TFEB) and its role in autophagy and neurodegenerative diseases.
Autophagy & Neurodegenerative Diseases
An overview of how cellular autophagy plays a role in brain health and neurodegeneration.
Neuromuscular Junction (NMJ) Morphology & ALS Models
Insights into neuromuscular junction (NMJ), its role in amyotrophic lateral sclerosis (ALS), and tools & methods used to study morphological changes in NMJs.
Autophagy, Parkinson's Disease, and Dopaminergic Neurons
An overview of how impaired autophagy can lead to pathologic changes and neurodegeneration in dopaminergic neurons in Parkinson’s disease.
ALS Mouse Models & Spinal Motor Neurons
An overview of the involvement of spinal motor neurons in disease progression in mouse models of Amyotrophic Lateral Sclerosis (ALS).
