What is EAE (Experimental Autoimmune Encephalomyelitis)?
An overview of EAE animal models of multiple sclerosis (MS), including pathophysiology and utilization of positive controls for preclinical therapeutic studies.
Mitochondrial Dysfunction & Parkinson's Disease
An overview of how mitochondrial dysfunction is associated with neurodegeneration in Parkinson’s disease.
Mitophagy and Parkinson’s Disease
An overview of how impaired mitophagy can lead to neurodegeneration in Parkinson’s disease.
Autophagy and Transcription Factor EB (TFEB)
An overview of Transcription Factor EB (TFEB) and its role in autophagy and neurodegenerative diseases.
Autophagy & Neurodegenerative Diseases
An overview of how cellular autophagy plays a role in brain health and neurodegeneration.
Neuromuscular Junction (NMJ) Morphology & ALS Models
Insights into neuromuscular junction (NMJ), its role in amyotrophic lateral sclerosis (ALS), and tools & methods used to study morphological changes in NMJs.
Autophagy, Parkinson's Disease, and Dopaminergic Neurons
An overview of how impaired autophagy can lead to pathologic changes and neurodegeneration in dopaminergic neurons in Parkinson’s disease.
ALS Mouse Models & Spinal Motor Neurons
An overview of the involvement of spinal motor neurons in disease progression in mouse models of Amyotrophic Lateral Sclerosis (ALS).
AAV α-Synuclein Models for Parkinson's Disease Drug Development
Overview of adeno-associated virus (AAV) induced α-synuclein expression in mouse & rat models for use in preclinical studies of disease-modifying therapeutics.
Amyloid-β Plaque Analysis in Alzheimer's Disease
Overview of methods to classify & quantify Aβ plaques in brain tissue sections from humans & Alzheimer’s disease animal models (transgenic mice & rats).
TDP-43 ΔNLS (rNLS8) Mice for ALS Drug Development
This resource provides information about the use of the ΔNLS (deltaNLS, hTDP-43ΔNLS, hTDP-43DeltaNLS, dNLS, TDP43 NLS, rNLS8) TDP-43 transgenic mouse model of ALS for preclinical therapeutic studies.
Demyelination & Remyelination in the Cuprizone Model
An overview of the methods available to measure myelin and oligodendrocytes in the cuprizone demyelination mouse model of multiple sclerosis (MS).
