Autophagy & Neurodegenerative Diseases
An overview of how cellular autophagy plays a role in brain health and neurodegeneration.
Neuromuscular Junction (NMJ) Morphology & ALS Models
Insights into neuromuscular junction (NMJ), its role in amyotrophic lateral sclerosis (ALS), and tools & methods used to study morphological changes in NMJs.
Autophagy, Parkinson's Disease, and Dopaminergic Neurons
An overview of how impaired autophagy can lead to pathologic changes and neurodegeneration in dopaminergic neurons in Parkinson’s disease.
Astrocyte Morphology in Alzheimer’s Disease
An overview of astrocyte morphological analysis and the applications to neurodegenerative disease research and drug discovery & development.
ALS Mouse Models & Spinal Motor Neurons
An overview of the involvement of spinal motor neurons in disease progression in mouse models of Amyotrophic Lateral Sclerosis (ALS).
AAV α-Synuclein Models for Parkinson's Disease Drug Development
Overview of adeno-associated virus (AAV) induced α-synuclein expression in mouse & rat models for use in preclinical studies of disease-modifying therapeutics.
Amyloid-β Plaque Analysis in Alzheimer's Disease
Overview of methods to classify & quantify Aβ plaques in brain tissue sections from humans & Alzheimer’s disease animal models (transgenic mice & rats).
Demyelination & Remyelination in the Cuprizone Model
An overview of the methods available to measure myelin & oligodendrocytes in the cuprizone demyelination mouse model of multiple sclerosis (MS).
Neurofilament Light Chain in Parkinson's Disease Models
How neurofilament light chain (NfL; NF-L) levels can be used as blood (plasma; serum) & CSF biomarkers in Parkinson's disease mouse and rat models.
Experimental Autoimmune Encephalomyelitis & Axonal Injury
This resource describes the methods available for measuring axonal damage & axon degeneration, including tissue markers and plasma & CSF neurofilament light chain (NfL; NF-L) levels, in the EAE model of multiple sclerosis (MS).
TDP-43 ΔNLS (rNLS8) Mice for ALS Drug Development
This resource provides information about the use of the ΔNLS (deltaNLS, hTDP-43ΔNLS, hTDP-43DeltaNLS, dNLS, TDP43 NLS, rNLS8) TDP-43 transgenic mouse model of ALS for preclinical therapeutic studies.
Microglia Morphology in ALS, Alzheimer's Disease & Parkinson's Disease
An overview of microglial morphological analysis and the applications to neurodegenerative disease research and drug discovery & development.
