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A white laboratory rodent perched on the edge of a blue-toned glass container, possibly a test tube or a beaker

We are the leading Preclinical Neuroscience CRO specializing in animal models of CNS diseases

We focus on providing research services leveraging the best available models of ALS, Alzheimer’s Disease, Multiple Sclerosis, and Parkinson's Disease

Our Neuroscience Animal ModelsOur Preclinical CRO Services
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Visit our Clinical Imaging CRO Website

We provide Imaging Core Lab services for clinical trials of neurological diseases.

Imaging CRO Services

Rodent Models

Learn more about our thoroughly characterized and validated animal models of neurological diseases

We have a range of transgenic and inducible mouse & rat models readily available for your studies. Our team of animal model scientists will work with you to find the right model.

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Staining used to highlight areas of neuronal degeneration or the presence of inclusions characteristic of the disease within the nervous system tissue
Amyotrophic Lateral Sclerosis (ALS)

TDP-43 mouse models with cytoplasmic aggregates, motor dysfunction, neurodegeneration, neuroinflammation, and neuromuscular changes.

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Staining used to highlight areas of neuronal degeneration or the presence of inclusions characteristic of the disease within the nervous system tissue
Amyotrophic Lateral Sclerosis (ALS)

TDP-43 mouse models with cytoplasmic aggregates, motor dysfunction, neurodegeneration, neuroinflammation, and neuromuscular changes.

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Alzheimer’s Disease - IHC staining
Alzheimer's Disease & Tauopathies

Amyloid-β and tau models with progressive pathologic changes in a well-defined spatiotemporal pattern.

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Multiple Sclerosis - a histological section of neural tissue stained to show cellular and structural details
Multiple Sclerosis (MS)

EAE, cuprizone, and other models that recapitulate the autoimmune inflammation, demyelination & remyelination, and neurodegeneration aspects of human disease.

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Parkinson's Disease - IHC staining
Parkinson's Disease

α-Synuclein preformed fibril (PFF) seeding & spreading models and AAV-induced α-synuclein mouse models recapitulating different aspects of Parkinson's disease.

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CRO Services

We provide a range of specialized research services tailored to models of CNS diseases

End-to-end contract research services from model generation to in-life testing to quantitative tissue & fluid biomarkers.

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A close-up of a medical syringe with a needle inserted into a small vial, likely a therapeutic agent

Animal Services

Our animal services team are experts in dosing via multiple routes of administration, stereotaxic surgical procedures, and fluid & tissue collection.

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Behavioral Testing - a three-dimensional maze with high walls, and within this maze, there's a white laboratory mouse looking out from one of the corridors.

Behavioral Testing

We use specific, validated tests that are sensitive to response to therapy in our CNS rodent models.

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A digital rendering of a neuron, which is a cell that transmits nerve impulses.

Electrophysiology

We use well-established, in vivo electrophysiological measures to evaluate motor and sensory function.

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A close-up of test tubes in a laboratory setting with a pipette dispensing a liquid into one of them

Fluid & Cellular Biomarkers

We can measure clinically translational biomarkers, such as neurofilament light, in blood and cerebrospinal fluid (CSF). We can also perform cellular immunophenotyping on a range of tissues, including brain, spinal cord, lymph nodes, and spleen.

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A series of MRI (Magnetic Resonance Imaging) brain scans displayed on a light box or a digital screen

Histology & Tissue Analysis

We have a state-of-the-art histopathology facility specializing in tissues collected from rodent models of neurological diseases.

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In Vivo Imaging of mouse brain

In Vivo Imaging

We use preclinical MRI, PET, and CT scanners, coupled with our advanced image processing & analysis techniques, to non-invasively measure changes in brain & muscle structure (e.g. atrophy) and function (e.g. metabolism, blood flow).

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Initiative

Microglia, Astrocytes, and Neurodegenerative Diseases

We explore the complex relationships between neuroinflammation and neurodegeneration, aiming to enhance scientific knowledge and accelerate the development of disease-modifying therapies.

 

By highlighting emerging scientific findings and reporting our original research, we seek to advance the understanding of how neuroinflammatory responses contribute to the onset and progression of neurodegenerative diseases, including ALS, Alzheimer's Disease & Tauopathies, and Parkinson's Disease. 

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TNF-α & Microglia in Neurodegenerative Diseases
An overview of the function of tumor necrosis factor-alpha (TNF-α) in microglia and its contribution to the progression of neurodegeneration.
Astrocyte Morphology in Alzheimer's Disease
An overview of astrocyte morphological analysis and the applications to neurodegenerative disease research and drug discovery & development.
NLRP3 Inflammasome and Neurodegenerative Diseases
An overview of the NLRP3 inflammasome and its role in neurodegenerative diseases, including Alzheimer's disease, Parkinson’s disease, and ALS.
Microglial Senescence and Neurodegenerative Diseases
An overview of microglial senescence and its role in neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD).
Astrocytes & Amyloid-β Mouse Models of Alzheimer's Disease
Analysis of astrocyte morphology in the amyloid-β plaque microenvironment provides a sensitive measure of disease progression in transgenic mice.
Lysosome Dysfunction in Microglia & Astrocytes
An overview of lysosomal dysfunction in microglia & astrocytes, and its role in neurodegenerative diseases.
Microglia Morphology in ALS, Alzheimer's Disease & Parkinson's Disease
An overview of microglial morphological analysis and the applications to neurodegenerative disease research and drug discovery & development.
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Our Latest Innovations

Narrated presentations of our scientific advancements

Scientific Resources

Up-to-date information on topics and best practices related to the evaluation of therapeutic agents in animal models of neurological diseases

  • All Resources
  • Amyotrophic Lateral Sclerosis (ALS)
  • Alzheimer's Disease
  • Parkinson's Disease
  • Multiple Sclerosis
Mitochondrial Dysfunction & Parkinson's Disease
An overview of how mitochondrial dysfunction is associated with neurodegeneration in Parkinson’s disease.
Mitophagy and Parkinson’s Disease
An overview of how impaired mitophagy can lead to neurodegeneration in Parkinson’s disease.
Autophagy and Transcription Factor EB (TFEB)
An overview of Transcription Factor EB (TFEB) and its role in autophagy and neurodegenerative diseases.
Autophagy & Neurodegenerative Diseases
An overview of how cellular autophagy plays a role in brain health and neurodegeneration.
Neuromuscular Junction (NMJ) Morphology & ALS Models
Insights into neuromuscular junction (NMJ), its role in amyotrophic lateral sclerosis (ALS), and tools & methods used to study morphological changes in NMJs.
Autophagy, Parkinson's Disease, and Dopaminergic Neurons
An overview of how impaired autophagy can lead to pathologic changes and neurodegeneration in dopaminergic neurons in Parkinson’s disease.
ALS Mouse Models & Spinal Motor Neurons
An overview of the involvement of spinal motor neurons in disease progression in mouse models of Amyotrophic Lateral Sclerosis (ALS).
AAV α-Synuclein Models for Parkinson's Disease Drug Development
Overview of adeno-associated virus (AAV) induced α-synuclein expression in mouse & rat models for use in preclinical studies of disease-modifying therapeutics.
Amyloid-β Plaque Analysis in Alzheimer's Disease
Overview of methods to classify & quantify Aβ plaques in brain tissue sections from humans & Alzheimer’s disease animal models (transgenic mice & rats).
Demyelination & Remyelination in the Cuprizone Model
An overview of the methods available to measure myelin and oligodendrocytes in the cuprizone demyelination mouse model of multiple sclerosis (MS).
Neurofilament Light Chain in Parkinson's Disease Models
How neurofilament light chain (NfL; NF-L) levels can be used as blood (plasma; serum) & CSF biomarkers in Parkinson's disease mouse and rat models.
Experimental Autoimmune Encephalomyelitis (EAE) & Axonal Injury
This resource describes the methods available for measuring axonal damage & axon degeneration, including tissue markers and plasma & CSF neurofilament light chain (NfL; NF-L) levels, in the EAE model of multiple sclerosis (MS).
TDP-43 ΔNLS (rNLS8) Mice for ALS Drug Development
This resource provides information about the use of the ΔNLS (deltaNLS, hTDP-43ΔNLS, hTDP-43DeltaNLS, dNLS, TDP43 NLS, rNLS8) TDP-43 transgenic mouse model of ALS for preclinical therapeutic studies.
ALS Mouse Models for Drug Development
A guide to the most effective use of research animal models (mouse & rat models) of Amyotrophic Lateral Sclerosis (ALS) for preclinical testing of therapeutics.
Autophagy and Transcription Factor EB (TFEB)
An overview of Transcription Factor EB (TFEB) and its role in autophagy and neurodegenerative diseases.
Autophagy & Neurodegenerative Diseases
An overview of how cellular autophagy plays a role in brain health and neurodegeneration.
Neuromuscular Junction (NMJ) Morphology & ALS Models
Insights into neuromuscular junction (NMJ), its role in amyotrophic lateral sclerosis (ALS), and tools & methods used to study morphological changes in NMJs.
ALS Mouse Models & Spinal Motor Neurons
An overview of the involvement of spinal motor neurons in disease progression in mouse models of Amyotrophic Lateral Sclerosis (ALS).
TDP-43 ΔNLS (rNLS8) Mice for ALS Drug Development
This resource provides information about the use of the ΔNLS (deltaNLS, hTDP-43ΔNLS, hTDP-43DeltaNLS, dNLS, TDP43 NLS, rNLS8) TDP-43 transgenic mouse model of ALS for preclinical therapeutic studies.
ALS Mouse Models for Drug Development
A guide to the most effective use of research animal models (mouse & rat models) of Amyotrophic Lateral Sclerosis (ALS) for preclinical testing of therapeutics.
Autophagy and Transcription Factor EB (TFEB)
An overview of Transcription Factor EB (TFEB) and its role in autophagy and neurodegenerative diseases.
Autophagy & Neurodegenerative Diseases
An overview of how cellular autophagy plays a role in brain health and neurodegeneration.
Amyloid-β Plaque Analysis in Alzheimer's Disease
Overview of methods to classify & quantify Aβ plaques in brain tissue sections from humans & Alzheimer’s disease animal models (transgenic mice & rats).
Mitochondrial Dysfunction & Parkinson's Disease
An overview of how mitochondrial dysfunction is associated with neurodegeneration in Parkinson’s disease.
Mitophagy and Parkinson’s Disease
An overview of how impaired mitophagy can lead to neurodegeneration in Parkinson’s disease.
Autophagy and Transcription Factor EB (TFEB)
An overview of Transcription Factor EB (TFEB) and its role in autophagy and neurodegenerative diseases.
Autophagy & Neurodegenerative Diseases
An overview of how cellular autophagy plays a role in brain health and neurodegeneration.
Autophagy, Parkinson's Disease, and Dopaminergic Neurons
An overview of how impaired autophagy can lead to pathologic changes and neurodegeneration in dopaminergic neurons in Parkinson’s disease.
AAV α-Synuclein Models for Parkinson's Disease Drug Development
Overview of adeno-associated virus (AAV) induced α-synuclein expression in mouse & rat models for use in preclinical studies of disease-modifying therapeutics.
Neurofilament Light Chain in Parkinson's Disease Models
How neurofilament light chain (NfL; NF-L) levels can be used as blood (plasma; serum) & CSF biomarkers in Parkinson's disease mouse and rat models.
Demyelination & Remyelination in the Cuprizone Model
An overview of the methods available to measure myelin and oligodendrocytes in the cuprizone demyelination mouse model of multiple sclerosis (MS).
Experimental Autoimmune Encephalomyelitis (EAE) & Axonal Injury
This resource describes the methods available for measuring axonal damage & axon degeneration, including tissue markers and plasma & CSF neurofilament light chain (NfL; NF-L) levels, in the EAE model of multiple sclerosis (MS).
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