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α-Synuclein preformed fibril (PFF) inoculation into a M83+/- transgenic mouse model of Parkinson's disease:
- Transgenic mice overexpressing α-synuclein with an A53T mutation
- Injection of recombinant, human PFFs into the Anterior Olfactory Nucleus (AON)
- Seeding and spreading of pathology to connected brain regions
- Progressive neurodegeneration (including MRI brain atrophy and elevated NfL in plasma & CSF)
- Strong microgliosis and astrogliosis in regions of ∝-synuclein pathology
α-Synuclein (p-Syn) pathology [top left], microgliosis (Iba-1) [top right], neurodegeneration (NeuN) [bottom left], and astrogliosis (GFAP) [bottom right] seen in the piriform cortex of M83+/- PFF mice after unilateral stereotaxic injection of α-synuclein PFFs into the AON.
Please note that we provide a link to all of our Parkinson's disease and other CNS disease models on the last page of this presentation.