Table of Contents
Abstract
01. Presentation OverviewPresentation
01. Introduction02. Neuroinflammation Classification03. Microglial Activation04. Plaque Microenvironment05. AD Mouse Model06. Age & Amyloid07. Age & Neuroinflammation08. Age & Microglial Activation09. Microenvironment Analysis10. Age & Inflammatory Microenvironment11. SummaryBy using a novel, robust, fully-automated approach, we have shown:
- We can measure the density of neuroinflammatory cells, including activated microglia, as function of distance to β-amyloid plaques.
- Our microenvironment analysis demonstrated:
- A very high level of activated microglia intimately associated with the plaques
- Age-dependent increase in neuroinflammation outside of the local plaque neighborhood
This approach may provide sensitive measures for the preclinical assessment of the efficacy of putative disease-modifying therapeutic agents in this mouse model of Alzheimer's disease.