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Representative snapshots of segmented β-amyloid plaques at various time points in the anterior cerebral cortex. The plaques are shown in red and the nuclei are shown in blue. The plaques identified by our algorithm are indicated by the white boxes.
Quantitative data showing age-dependent increase in the density of β-amyloid plaques in the cerebral cortex of ARTE10 mouse model. N=10-12 mice per group. Statistical analysis was performed using Kruskal-Wallis non-parametric test and Dunn’s multiple comparisons test. *p<0.05; **p<0.005; ***p<0.001; ****p<0.0001.