Table of Contents
Regional Volumes
Brain volumes in various cortical and subcortical regions. The arrows show the progression of Off Dox mice that either continued off doxycycline until 6 weeks or were put back on doxycycline for 3 weeks. * p<0.05; ** p<0.01; *** p<0.001; **** p<0.0001
Cortical Thickness
Cortical thickness measures in the motor and frontal cortical regions. The arrows show the progression of Off Dox mice that either continued off doxycycline until 6 weeks or were put back on doxycycline for 3 weeks. * p<0.05; ** p<0.01; *** p<0.001; **** p<0.0001
Cortical thickness map demonstrating the regions of cortical thinning in Low Dox compared to control mice. The colder colors (e.g. blue, purple) represent areas with significant atrophy. Note the high degree of specificity for the motor and frontal cortex at 8 weeks following disease initiation.