Automated MRI-Based Analysis of Regional Brain Volumes

Table of Contents

Abstract

Presentation

01. Introduction 02. Regional Volumes Analysis Methods 03. Cortical Thickness Analysis Methods 04. TDP-43 Model 05. TDP-43 Model MR Images 06. TDP-43 Model MRI Analysis 07. Alpha-Synuclein Model 08. Synuclein Model MR Images 09. Synuclein Model MRI Analysis 10. Summary

https://opt003stagmediafiles.blob.core.windows.net/image/6bca84e11d3a487eb61f7c7cc1ff1f0b

Illustration of our fully-automated approach for generating regional volumes from mouse brains.

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Our team has developed an entire software platform for processing and analysis of MRI scans of rodent brains. Our methods are automated and do not require any manual measurements or corrections.

Briefly, all native anatomical MRI scans are spatially normalized to a standardized anatomical coordinate space. The individual, preprocessed images are linearly and non-linearly registered to an anatomical template. An atlas with predefined neuroanatomical structures is then applied, allowing for regional volumetric measures. We also apply a cortical mask, which is used for thickness analysis, as described on the next page.