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Table of Contents

Table of Contents

Abstract
01. Abstract
Presentation
01. Introduction02. Microenvironment Analysis Pipeline03. Astrocyte Processing Pipeline04. Astrocyte Classification05. Hypertrophy Score06. APP/PS1 Mouse Model07. Astrocyte Hypertrophy08. Astrocyte Morphology Score & Disease Progression09. Region-dependent Changes10. Quantifying Plaque Size11. Cellular Microenvironment & Plaque Size12. Summary

The Interactive Image Viewer below allows you to explore the entire multiplex immunofluorescence tissue section.

You can pan around the image using the left mouse button. You can zoom in & out using the mouse/trackpad (up/down) or the + and - buttons in the upper left corner. You can toggle (on/off), change color, and adjust image settings for the channels and segmentations in the Control Panel in the upper right corner.

In this visualization, an APP/PS1 (ARTE10) mouse brain is shown with the "hypertrophic astrocyte" bounding box (blue) and the "normal astrocyte" bounding box (teal), along with the "Iba-1 microglia" (green), "GFAP astrocyte"  (yellow), and "Amyloid-β" staining (red), which can be checked/unchecked to hide/show the spatial relationships.

Control Panel
Section: APP/PS1 Mouse
Segmentations
Channels
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In this multiplex immunofluorescence brain section from a 9 month-old APP/PS1 transgenic mouse, we can observe the spatial relationships between amyloid-β plaques, astrocytes, and microglia. The normal and hypertrophic astrocytes are identified by the colored boxes.

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