Cuprizone Models of Multiple Sclerosis (MS)

We offer preclinical studies with both the cuprizone (CPZ) mouse model and the cuprizone + rapamycin (CPZ + RAPA) mouse model. Cuprizone-induced demyelination is a standard model of Multiple Sclerosis (MS). Note: we also have the EAE model of MS.

These inducible demyelination models involve reversible demyelination of the corpus callosum by including cuprizone in the diet.  When cuprizone is removed from the diet, remyelination spontaneously occurs. 

EAE Model Multile Sclerosis

These rodent models are used in preclinical efficacy assessments of therapeutics related to

  • Demyelination/remyelination
  • Neuroinflammation

At Biospective, we offer preclinical studies with our well-characterized and validated in-house models, as well as with commercially-available and sponsor-provided models. Our end-to-end preclinical studies include breeding, housing, dosing, in vivo imaging (MRI & PET), behavior and functional assessments, and immunohistochemistry (IHC).