Biospective’s in vivo Tau transgenic mice and Tau fibril spreading models demonstrate a rapidly progressive and robust propagation of tau pathology. These models rely on the inoculation of synthetic tau fibrils to initiate Alzheimer’s disease-like intracellular neurofibrillary tangles and transmit the pathology to anatomically-connected brain regions. Common injection sites include the hippocampus, the cerebral cortex, and the anterior olfactory nucleus (AON).