EAE Model of Multiple Sclerosis (MS)

We offer preclinical studies with the EAE (Experimental Autoimmune Encephalomyelitis) mouse model. EAE is a standard model of Multiple Sclerosis (MS). Note: we also have cuprizone models of MS.

The EAE model involves induction of an autoimmune response with a resultant inflammatory and demyelinating response recapitulating aspects of human MS.

EAE Model

This rodent model is used in preclinical efficacy assessments of therapeutics related to

  • Demyelination/remyelination
  • Neuroprotection
  • Neuroinflammation
  • Peripheral inflammation & autoimmunity

At Biospective, we offer preclinical studies with our well-characterized and validated in-house models, as well as with commercially-available and sponsor-provided models. Our end-to-end preclinical studies include breeding, housing, dosing, in vivo imaging (MRI & PET), behavior and functional assessments, and immunohistochemistry (IHC).