We are a neuroimaging-focused CRO with a strong track record of delivering top quality results in early and late phase clinical trials across a range of diseases
Our multidisciplinary team provides the full spectrum of Imaging Core Lab services, including imaging study operations, central eligibility & safety reads, and quantitative image processing & analysis
Our Latest Innovations
Narrated presentations of our scientific advancements
Reduction of brain glucose metabolism in MCI is primarily driven by tau pathologyUpdated Mar 1, 202410 min presentation
By applying a singular value decomposition (SVD) analysis to tau, amyloid, and FDG PET images from MCI subjects in the ADNI study, we demonstrate a more significant role of tau than β-amyloid in the reduction of cerebral glucose metabolism.
Spatial association between distributed β-amyloid and tau varies with cognitionUpdated Mar 1, 202410 min presentation
Through the use of a novel computational approach that accounts for both linear and nonlinear relationships, we have found that β-amyloid and tau act in a spatially coordinated manner that depends on the cognitive stage of Alzheimer's disease.
A novel computational method for harmonization of brain PET image spatial resolution without phantomsUpdated Mar 1, 202410 min presentation
We have developed a method for estimation of spatial resolution directly from brain PET images, called SPITFIRE™, and used the resultant smoothing kernel to harmonize the resolution of amyloid PET images and compared to results of phantom-based smoothing.