Spatial Biology  

By employing various imaging modalities such as fluorescence microscopy, confocal microscopy, and multiplexed imaging, spatial biology aims to capture detailed spatial information, including subcellular localization, molecular interactions, and cellular architecture. Analyzing these spatial relationships provides insights into the complex mechanisms underlying biological processes, cell signaling, disease pathology, and the microenvironment's influence on cellular behavior.

Spatial biology in microscopy enables researchers to unravel intricate biological phenomena by examining biological entities within their spatial dimensions, allowing for a deeper comprehension of biological systems and paving the way for targeted therapeutic interventions. 

At Biospective, our multidisciplinary R&D team is combining whole-section multiplex immunofluorescence images with machine-learning algorithms to perform high-dimensional phenotyping and explore the spatial relationships between various cell types. One example is our work to interrogate the relationship between β-amyloid plaques and the inflammatory microenvironment using our APP/PS1 mouse model of Alzheimer's disease.

Read More in our Presentation - β-amyloid & the inflammatory microenvironment in an APP/PS1 mouse model of Alzheimer's disease