Core Imaging Lab

Biospective has a solid track-record of delivering top quality results in Phase Ib, Phase II, and Phase III studies across CNS therapeutic areas, including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, ALS, neurodevelopmental disorders, and neuropsychiatric diseases. We are a full-service Core Imaging Lab and can provide expertise and services to support all of the demands of small to large-scale studies. Our advanced technologies (PIANO™ for fully-automated image processing, and GRETEL™ for web-based project and electronic data management, and high-throughput image QC review) set us apart from other CROs.


Consultation for Imaging Study Design

Imaging Site Management during Study

Statistical Image Analysis

Clinical Imaging Site Qualification

Rigorous Image Quality Control Review

Project and Data Management

Preparation of Image Acquisition Guidelines

Fully-automated, Multi-modality Image Processing

Scientific Reporting

Imaging Modalities

Biospective has substantial experience with a wide range of MRI (vMRI, fMRI, diffusion MRI/DTI, ASL MRI, SWI, neuromelanin), PET (amyloid, tau, FDG), and SPECT (DaTscan).

Advanced Image Processing

PIANO™ is our industry-leading, fully-automated image processing platform for clinical CNS studies. This 21 CFR Part 11 compliant, validated software includes core modules for all available MRI, PET, and SPECT neuroimaging techniques. The comprehensive, advanced, multi-modality capabilities of PIANO™ are unparalleled.


Project & Electronic Data Management


GRETEL™ is a cross-platform (computer, tablet, smartphone), modular, web-based application that provides full transparency into your clinical study. The power of the GRETEL™ Project and Electronic Data Management module stems from its ability to combine clinical, neuropsychiatric, imaging, and digital biomarker data from all subjects into a single, user-friendly system.

Quality Control


Careful attention to raw and processed image quality is paramount to a successful imaging study. In addition to our detailed SOPs, Biospective has developed a unique solution for rapid, yet rigorous, image QC as part of our GRETEL™ software package.