We are the leading neuroscience preclinical CRO specializing in rodent models of CNS diseases
We focus on providing services leveraging the best available models of ALS, Alzheimer’s Disease, Multiple Sclerosis, and Parkinson's Disease
Learn more about our thoroughly characterized and validated models of CNS diseases
We have a range of transgenic and inducible models readily available for your studies. Our team of animal model scientists will work with you to find the right model.
TDP-43 mouse models with cytoplasmic aggregates, motor dysfunction, neurodegeneration, and neuromuscular changes.
β-amyloid and tau models with progressive pathologic changes in a well-defined spatiotemporal pattern.
EAE, cuprizone, and other models that recapitulate the autoimmune, demyelinating/remyelinating, and neurodegenerative aspects of human disease.
We provide a range of specialized research services tailored to models of CNS diseases
End-to-end services from model generation to in-life testing to quantitative tissue & fluid biomarkers.
- Animal Services
- Behavioral Testing
- Fluid & Cellular Biomarkers
- Histology & Tissue Analysis
- In Vivo Imaging
Our animal services team are experts in dosing via multiple routes of administration, stereotaxic surgical procedures, and fluid & tissue collection.
Our Latest Innovations
Narrated presentations of our scientific advancements
Microglial activation in an α-synuclein mouse model of Parkinson’s diseaseUpdated Oct 16, 202310 min presentation
Leveraging computer vision and machine learning algorithms, we have quantified microglial activation in immunohistochemistry (IHC) sections from an α-synuclein preformed fibril (PFF) seeding & spreading mouse model.
β-amyloid & the inflammatory microenvironment in an APP/PS1 mouse model of Alzheimer’s diseaseUpdated Dec 14, 202310 min presentation
By applying advanced image analysis techniques to multiplex immunofluorescence data, we have been able to explore spatiotemporal changes in the inflammatory microenvironment of β-amyloid plaques in an APP/PS1 transgenic model.
Brain atrophy analysis in rodent models of neurodegenerationUpdated Dec 18, 202310 min presentation
Brain atrophy is a hallmark of many neurodegenerative diseases. MRI is routinely used in clinical trials to non-invasively measure volumetric and cortical thickness changes. We have applied these translational imaging biomarkers to mouse models of ALS and Parkinson’s disease.