News & Events

  • Biospective is excited to be speaking about the Challenges and Opportunities of Digital Biomarkers in Clinical Trials during the "Digital Biomarkers: How to Implement" session on Friday November 17th at the CNS Summit in Boca Raton this year! We look forward to seeing you there. Please send us a message if you would like to meet with us about our digital biomarker capabilities.

  • Biospective clinical scientist Donald McLaren will present our latest work, how quantitative amyloid imaging can reduce screening numbers and enrollment time in clinical trials, at the 10th Clinical Trials on Alzheimer's Disease (CTAD) meeting in Boston from November 1st-4th, 2017. Please stop by our poster (P53) on Friday or Saturday to learn more or send us a message by clicking on the logo to setup a meeting.

  • Biospective showcased our new project and data management tool: "GRETEL™: A Platform for Management of Digital Biomarkers in Clinical Trials” at the 4th annual Mobile in Clinical Trials Conference held in Boston on September 6th, 2017. Click the logo for more information about GRETEL™.

  • Biospective is excited to have presented at Disruptive Innovations on September 7th and 8th in Boston this year! Our talk was titled: “GRETEL™: A Platform for Management of Digital Biomarkers in Clinical Trials”. Click the logo more information about the talk.

Publications

We have an active internal R&D program and on-going collaborations with researchers around the world. We continually present our work at international scientific conferences and regularly publish in high-impact, peer-reviewed journals. Publications from members of our scientific team include:

Bernard-Gauthier V, Bailey JJ, Mossine AV, Lindner S, Vomacka L, Aliaga A, Shao X, Quesada CA, Sherman P, Mahringer A, Kostikov A, Grand’Maison M, Rosa-Neto P, Soucy JP, Thiel A, Kaplan DR, Fricker G, Wängler B, Bartenstein P, Schirrmacher R, Scott PJH. A Kinome-Wide Selective Radiolabeled TrkB/C Inhibitor for in Vitro and in Vivo Neuroimaging: Synthesis, Preclinical Evaluation, and First-in-Human. J Med Chem. 2017 Jul 21. doi: 10.1021 / acs.jmedchem.7b00396. (Epub ahead of print)

Coutu JP, Lindemer ER, Konukoglu E, Salat DH, Alzheimer’s Disease Neuroimaging Initiative (ADNI). Two distinct classes of degenerative change are independently linked to clinical progression in mild cognitive impairment. Neurobiology of Aging 2017;54:1-9.

Iturria-Medina, Y., Carbonell, F., Sotero, F., Chouinard, F., Evans, A. C. Multifactorial Causal Model of Brain (dis)Organization and Therapeutic Intervention: application to Alzheimer’s Disease. NeuroImage, 2017;152:60-77.

Khalili-Mahani, N., Rombouts, S., van Osch, M., Duff, E., Carbonell, F., Nickerson, L., Becerra, L., Dahan, A., Evans, A. C., Soucy, J. P., Wise, R. G., Zijdenbos, A. P., van Gerven, J. Biomarkers, Designs and Interpretations of Resting-State fMRI in Translational Pharmacological Research: a review of state-of-the-art, challenges and opportunities for studying brain. Human Brain Mapping, 2017; 38(4):2276-2325.

Kumdrakpam, B. S., Lewis, J. D., Kostopoulos, P., Carbonell, F., Evans, A. C. Cortical Thickness Abnormalities in Autism Spectrum Disorders Through Late Childhood, Adolescence, and Adulthood: A Large-Scale MRI Study. Cerebral Cortex, 2017; 27(3):1721-1731.

Coutinho A.M., Coutu J.P., Lindemer E.R., Rosas H.D., Rosen B.R., Salat D.H. Differential associations between systemic markers of disease and cortical thickness in middle-aged and older adults, Neuroimage, 2017; 146:19-27

Vannini P, Amariglio R, Hanseeuw B, Johnson KA, McLaren DG, Chhatwal J, Pascual-Leone A, Rentz D, Sperling RA. Memory self-awareness in the preclinical and prodromal stages of Alzheimer’s disease. Neuropsychologia 2017; 99:343-349

DeDuck K, Brison E, Zehntner SP, Zijdenbos AP, Luk KC , Bedell BJ. Olfactory dysfunction, regional brain atrophy, and pathologic spreading in an inducible mouse model of α-synucleinopathy. International Conference on Alzheimer’s and Parkinson’s Diseases International Conference (ADPD) 2017, Vienna, Austria.

Hohman TJ, McLaren DG, Mormino EC, Gifford KA, Libon DJ, Jefferson AL; Alzheimer’s Disease Neuroimaging Initiative. Asymptomatic Alzheimer’s disease: Defining resilience. Neurology 2016;87(23):2443-2450. 

Vincent RD, Neelin P, Khalili-Mahani N, Janke AL, Fonov VS, Robbins SM, Baghdadi L, Lerch J, Sled JG, Adalat R, MacDonald D, Zijdenbos AP, Collins DL, Evans AC. MINC 2.0: A Flexible Format for Multi-Modal Images. Front Neuroinform. 2016;10:35. 

Nguyen TM, Wu QM. Multiple Kernel Point Set Registration. IEEE Trans Med Imaging. 2016;35(6):1381-94. 

Nguyen TM, Wu QM. A Consensus Model for Motion Segmentation in Dynamic Scenes. IEEE Trans. Circuits Syst. Video Techn. 2016;26(12): 2240—2249. 

Nguyen TM, Wu QM. Online Feature Selection Based on Fuzzy Clustering and Its Applications. IEEE Trans. Fuzzy Systems. 2016;24(6): 1294—1306. 

Carbonell F, McLaren DG, Zijdenbos AP, Bedell BJ. Uncovering the Relationship between Metabolism and β-amyloid in Mild Cognitive Impairment. Alzheimer’s Association International Conference 2016. Toronto, ON, Canada. 

Carbonell, F. , Zijdenbos, A. P., McLaren, D. G., Iturria-Medina, Y., Bedell, B. J. Modulation of glucose metabolism and metabolic connectivity by β-amyloid. Journal of Cerebral Blood Flow and Metabolism, 2016; 36(12):2058-2071. 

Brison E, Zehntner SP, Zijdenbos AP, Luk KC , Bedell BJ. Assessment of olfactory dysfunction in an inducible mouse model of α-synucleinopathy via multi-modality imaging . 4th World Parkinson Congress (WPC) 2016, Portland, Oregon, USA.

Carbonell F, Zijdenbos AP, Charil A, Grand’Maison M, Bedell BJ; Alzheimer’s Disease Neuroimaging Initiative. Optimal Target Region for Subject Classification on the Basis of Amyloid PET Images. J Nucl Med 2015;56(9):1351-8. 

Bellec, P., Benhajali, Y., Carbonell, F., Dansereau, C., Albouy, G., Pelland, M., Craddock, C., Collignon, O., Doyon, J., Stip, E., Orban, P. Multiscale statistical testing for connectome-wide association studies in fMRI, NeuroImage, 2015;123, 212-228. 

Carbonell F, Charil A, Zijdenbos AP, Evans AC, Bedell BJ; Alzheimer’s Disease Neuroimaging Initiative. Hierarchical multivariate covariance analysis of metabolic connectivity. J Cereb Blood Flow Metab. 2014;34(12):1936-43. 

Carbonell, F., Bellec, P., Shmuel, A. Quantification of the impact of a confounding variable on functional connectivity confirms anti-correlated networks in the resting-state. NeuroImage. 2014;86:343-53. 

Carbonell F, Charil A, Zijdenbos AP, Evans AC, Bedell BJ. β-Amyloid is associated with aberrant metabolic connectivity in subjects with mild cognitive impairment. J Cereb Blood Flow Metab. 2014;34(7):1169-79. 

Grand’Maison, M., Zehntner, S. P., Ho, M-K., Hébert, F., Wood, A., Carbonell, F., Zijdenbos, A. P., Hamel, E., Bedell, B. J. Early cortical thickness changes predict beta-amyloid deposition in a mouse model of Alzheimer’s disease. Neurobiology of Disease. 2013; 54, 59-67. 

Hébert F, Grand’Maison M, Ho M-K, Lerch JP, Hamel E, Bedell BJ. Cortical atrophy and hypoperfusion in a transgenic mouse model of Alzheimer’s disease. Neurobiology of Aging. 2013 34(6):1644-52 

Dugger BN, Clark CM, Serrano G, Mariner M, Bedell BJ, Coleman RE, Doraiswamy PM, Lu M, Fleisher AS, Reiman EM, Sabbagh MN, Sadowsky CH, Schneider JA, Zehntner SP, Carpenter AP, Joshi AD, Mintun MA, Pontecorvo MJ, Skovronsky DM, Sue LI, Beach TG. Neuropathologic heterogeneity does not impair florbetapir-positron emission tomography postmortem correlates. J Neuropathol Exp Neurol. 2014;73(1):72-80. 

S.P. Zehntner, M. Grand’Maison, A. Wood, A. P. Zijdenbos, A-M. Steff, B. J. Bedell. Automated Quantitative Image Analysis of Goblet Cell Hyperplasia in a Mouse Model of RSV Infection RSV Vaccines for the World Congress. Oporto Portugal 2013. (see attached Poster image) 

S. Bhardwaj, A. Al-Shammari, S. P. Zehntner, M. Grand’maison, A. Mathieu, B. Courcot, B. J. Bedell, F. Szele, L. K. Srivastava. Neonatal immune activation-induced changes in brain volume, neurogenesis and behavior in mice – moderation by dysbindin-1 gene. SfN 2013.

S P. Zehntner, Alex P. Zijdenbos, Barry J. Bedell, Diego Cadavid. Co-Registration of DTI and MTR MRI Data to Quantitative Immunohistochemistry in a Novel Mouse Model of Inflammatory Cerebral Demyelination” 65th Annual Meeting of the American Academy of Neurology, San Diego April 26-May3, 2013. 

Ming-Kai Ho, Alex P. Zijdenbos, SP. Zehntner, François Hébert, Marilyn Grand’Maison, Barry J. Bedell. Distinct Cortical Laminar Patterns of Amyloid Deposition and Astrogliosis in a Mouse Model of Alzheimer’s Disease. ADPD 6-10 March 2013.

Charil, A., Carbonell, F., Zijdenbos, A.P., Bedell, B.J. Vertexwise discriminant analysis of ADNI [18F]florbetapir PET images for classification of amyloid-positive and amyloid-negative subjects, Alzheimer’s and Dementia 9(4), Supplement, July 2013, Page P867. 

Grand’Maison M, Zehntner SP, Ho M-K, Hébert F, Wood A, Carbonell F, Zijdenbos AP, Bedell BJ. 3D ex vivo amyloid imaging and the relationship with MRI-derived measures of cortical thickness in an Alzheimer’s disease mouse model. Human Amyloid Imaging Conference 2013, Miami, FL, USA. 

Khundrakpam BS, Reid A, Brauer J, Carbonell F, Lewis J, Ameis S, Karama S, Lee J, Chen Z, Das S, Evans AC. Developmental changes in organization of structural brain networks. Cereb Cortex 2013;23(9):2072-2085. 

Charil A, Carbonell F, Zijdenbos AP, Evans AC, Bedell BJ. Amyloid-associated alterations in metabolic connectivity patterns in ADNI participants, Alzheimer’s and Dementia 2013;9(4), Supplement, P418-P419. 

Ho M-K, Zijdenbos ZP, Zehntner SP, Hébert F, Grand’Maison M, Bedell BJ. Distinct cortical laminar patterns of amyloid deposition and astrogliosis in a mouse model of Alzheimer’s disease. Alzheimer’s & Parkinson’s Diseases Congress 2013, Florence, Italy.

Fleisher, A.S., Schneider, J.A., Beach, T.G., Bedell, B., Zehntner, S.P., Gamez,J., Sicuro,F., Patel,M., Sabbagh,M. Clarck, C.C., Krautkramer,M., POntecorvo,M.J., Joshi, A., Mintun,M.A., Flitter,M. Hefti, F.F., Skovronsky,D.M. Histopathological Validation of Amyloid Imaging with F18 (18F-AV-45) PET in an ongoing Phase III Prospective Clinical Study of Subjects at the end of life. 62nd Annual Meeting of the American Academy of Neurology, Toronto, April 10-17, 2012

Hébert F, Ho M-K, Hamel E, Lerch JP, Bedell BJ. MRI-Derived Cortical Thickness Measurements of APP Transgenic Mice. Alzheimer’s Association International Conference on Alzheimer’s Disease (AAIC), Paris, France, July 10-16, 2011.

Hébert F, Ho M.-K, Hamel E, Bedell BJ. Neuroanatomical Volumes from MRI Studies of Young, Middle-Aged, and Old APP Transgenic Mice. Alzheimer’s Association International Conference on Alzheimer’s Disease (ICAD), Paris, France, July 10-16, 2011.

Grand’Maison M, Hébert F, Ho M-K, Bedell BJ. MR imaging of arterial dysfunction in a transgenic mouse model of Alzheimer’s disease. Alzheimer’s Association International Conference 2012, Vancouver, BC, Canada. 

Carbonell F, Charil A, Reid A, Zijdenbos AP, Evans AC, Bedell BJ. Functional network analysis of florbetapir-low and florbetapir-high ADNI MCI subjects, Alzheimer’s and Dementia 2012;8(4), Supplement, S17. 

Choi SR, Schneider JA, Bennett DA, Beach TG, Bedell BJ, Zehntner SP, Krautkramer MJ, Kung HF, Skovronsky DM, Hefti F, Clark CM. Correlation of amyloid PET ligand florbetapir F 18 binding with Aβ aggregation and neuritic plaque deposition in postmortem brain tissue.Alzheimer’s Dis Assoc Disord 2012;26(1):8-16.
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Clark CM, Pontecorvo MJ, Beach TG, Bedell BJ, Coleman RE, Doraiswamy PM, Fleisher AS, Reiman EM, Sabbagh MN, Sadowsky CH, Schneider JA, Arora A, Carpenter AP, Flitter ML, Joshi AD, Krautkramer MJ, Lu M, Mintun MA, Skovronsky DM. Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-β plaques: a prospective cohort study. Lancet Neurol 2012;11(8):669-678. 

Clark CM, Schneider JA, Bedell BJ, Beach TG, Bilker WB, Mintun MA, Pontecorvo MJ, Hefti F, Carpenter AP, Flitter ML, Krautkramer MJ, Kung HF, Coleman RE, Doraiswamy PM, Fleisher AS, Sabbagh MN, Sadowsky CH, Reiman EP, Reiman PEM, Zehntner SP, Skovronsky DM. Use of florbetapir-PET for imaging beta-amyloid pathology. JAMA 2011;305(3):275-283. 

T. Bertomeu, V. Zvereff, A. Ibrahim, S.P. Zehntner, A. Aliaga, P. Rosa-Neto, B.J. Bedell, P. Falardeau and H. Gourdeau. TLN-4601 peripheral benzodiazepine receptor (PBR/TSPO) binding properties do not mediate apoptosis but confer targeted delivery to brain tumors. Biochem Pharmacol Biochem Pharmacol. 2010;80(10):1572-9. 

Bedell B.J, Cakirogl, J, Ella A, Hébert F, Ho M-K, Yu J, Hamel E. Arterial spin labeling perfusion magnetic resonance imaging of aged amyloid precursor protein transgenic mice. Alzheimer’s Association International Conference on Alzheimer’s Disease (ICAD), Honolulu, HI, July 10-15, 2010.

Miron V. E., Zehntner S. P., Kuhlmann T., Ludwin S., Owens T., Kennedy T. E., Bedell B. J., and J. P. Antel. Statin Therapy Inhibits Remyelination in the Central Nervous System. Am J Path. Am J Pathol.2009;174(5):1880-90.

Rafei M., Hsieh J., Zehntner S.P., Li M., Forner K., Birman E., Boivin M.N., Young Y.K., Perreault C., and J Galipeau. A granulocyte-macrophage colony-stimulating factor and interleukin-15 fusokine induces a regulatory B cell population with immune suppressive properties.Nat Med. 2009;15(9):1038-45. 

Zehntner, S. P., M. M. Chakravarty, R. J. Bolovan, C. Chan and B. J. Bedell. Synergistic tissue counterstaining and image segmentation techniques for accurate, quantitative immunohistochemistry. J Histochem Cytochem. 2008;56(10): 873-880.

Chakravarty, M.M., Bedell, B.J., Zehntner, S.P., Evans, A.C., Collins, D.L. Three-dimensional reconstruction of serial histological mouse brain sections. 5th IEEE International Symposium on Biomedical Imaging, Paris, France, May 14-17, 2008

Remington, L. T., A. A. Babcock, S. P. Zehntner and T. Owens. Microglial recruitment, activation, and proliferation in response to primary demyelination. Am J Pathol. 2007;170(5): 1713-1724. 

Charil A, Dagher A, Lerch JP, Zijdenbos AP, Worsley KJ, Evans AC. Focal Cortical Atrophy in Multiple Sclerosis: Relation to Lesion Load and Disability. NeuroImage 2007; 34: 509-517. 

Bourbeau, D., C. J. Lau, J. Jaime, Z. Koty, S. P. Zehntner, G. Lavoie, A. M. Mes-Masson, J. Nalbantoglu and B. Massie. Improvement of antitumor activity by gene amplification with a replicating but nondisseminating adenovirus. Cancer Res. 2007; 67(7): 3387-3395. 

Zehntner, S. P., L. Bourbonniere, C. S. Moore, S. J. Morris, D. Methot, M. St Jean, E. Lacasse, A. L. Hebb, G. S. Robertson, J. Durkin, J. W. Gillard and T. Owens. X-linked inhibitor of apoptosis regulates T cell effector function. J Immunol. 2007;179(11):7553-7560. 

Wheeler, R. D., S. P. Zehntner, L. M. Kelly, L. Bourbonniere and T. Owens. Elevated interferon gamma expression in the central nervous system of tumour necrosis factor receptor 1-deficient mice with experimental autoimmune encephalomyelitis. Immunology. 2006;118(4): 527-538. 

Brisebois M, Zehntner SP, Estrada J, Owens T, Fournier S. A pathogenic role for CD8+ T cells in a spontaneous model of demyelinating disease. J Immunol 2006;177(4):2403-2411. 

Kuhlmann T, Remington L, Cognet I, Bourbonniere L, Zehntner S, Guilhot F, Herman A, Guay-Giroux A, Antel JP, Owens T, Gauchat JF. Continued administration of ciliary neurotrophic factor protects mice from inflammatory pathology in experimental autoimmune encephalomyelitis. Am J Pathol 2006;169(2):584-598. 

Zehntner SP, Brickman C, Bourbonnière L, Remington L, Caruso M, Owens T. Neutrophils that infiltrate the central nervous system regulate T cell responses. J Immunol 2005;174(8):5124-5131. 

Zehntner, S. P., L. Bourbonniere, M. Hassan-Zahraee, E. Tran and T. Owens. Bone marrow-derived versus parenchymal sources of inducible nitric oxide synthase in experimental autoimmune encephalomyelitis. J Neuroimmunol. 2004;150(1-2):70-79.

Tohka J, Zijdenbos A, Evans A. Fast and robust parameter estimation for statistical partial volume models in brain MRI. Neuroimage 2004;23(1):84-97. 

Kuhlmann T, Remington L, Cognet I, Bourbonniere L, Zehntner S, Guilhot F, Herman A, Guay-Giroux A, Antel JP, Owens T, Gauchat JF. Continued administration of ciliary neurotrophic factor protects mice from inflammatory pathology in experimental autoimmune encephalomyelitis. Am J Pathol 2006;169(2):584-598. 

Brochures

Clinical Imaging Capabilities

Digital Biomarker Capabilities

Alzheimer’s Disease Models

CNS Preclinical Capabilities

Multiple Sclerosis Models

Parkinson’s Disease Models